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New Chemical Substance Notification

    NCSN Introduction

    1 NCSN

    In order to enhance the environmental management and control the environmental risk on new chemical substances, prevent environmental pollution, and protect human health and safeguard the ecological environment, MEP issue the “Provisions on the Environmental Administration of New Chemical substances”. According to the Provision, “new chemical substance” means any chemical substance which has not yet been listed in the Inventory of Existing Chemical Substances Manufactured or Imported in China (IECSC). Any manufacturer or importer of new chemical substances shall, prior to the manufacture or import of new chemical substances, make notifications and applications for the registration certificates for the environmental management on new chemical substances (hereinafter cited as ‘the registration certificates’) in compliance with this Provisions.

    General Notification

    Simple Notification

    Scientific and Research Record Notification

    (Ministry of Environmental Protection of the People’s Republic of China Statute No.7)

    2 Solid Waste and Chemicals Management Technology Centre of MEE, SCC-MEE

    Solid Waste and Chemicals Management Technology Centre of MEP was established in June 2013. It was formed by combining the former solid waste management center of MEP and the former Chemical Registration Center of MEP. Its name was changed to Solid Waste and Chemicals Management Technology Centre of MEE in May 2019. It is a bureau level institution directly under MEE. It is a technique supporting sub-institute for management of solid waste, chemicals, contaminated sites and heavy metal environment of MEE.

    3 OCI NCSN Department and Team

    OCI is one of the first companies to focus on new chemical substances notification (NCSN), and has accumulated rich experience.

    In the actual operation of many years, the company has successfully established a sophisticated core technology team, covering all aspects of the business, able to give feedback to the customer's information in time, meeting the various needs of the customers from different angles, and attracting more and more attention in the rapid development of China and the petrochemical industry. OCI provides you with excellent new chemical substance notification service.

    4 Advantages of OCI

    The optimum experiment plan, the shortest processing time and the best results are from:

    (1) Our professional team and long-term stable partner relationships with well-known laboratory at home and abroad

    (2) The support of hygeian toxicology and ecotoxicology experts at home and abroad

    (3) Close relationship with relevant authorities

    (4) Abundant data resources

    (5) The perfect commercial secrecy system

    Services of NCSN

    Items Description

    IECSC check

    Public or confidential

    Initial assessment

    Assess the notification type via the usage, quantity and Sponsor

    Notification plan

    Base on the existing data, notification type and exposure information

    Periodic report

    Update by month or quarter

    Translating reports

    Review the acceptability

    Translating the summary

    Arranging the tests

    Different price level labs for choice

    Contract with the selected lab

    Update by month or quarter

    Review the test results

    Send the test results to the Sponsor

    Test waiver

    Base on the existing data, usage and exposure information

    Risk assessing report

    Propose the control measures via the physicochemical, toxicity and eco-toxicity data, usage and exposure information,

    Notification dossiers

    Preparing the test data

    Compiling the environmental risk assessing report

    Compiling or translating MSDS, GHS labels

    Submitting the dossiers

    MSDS, GHS labels

    Based on the existing data and original version, in compliance with Chinese regulations

    NCSN Tests

    OECD No. Chinese Name English Name
    Section 1 Physis-Chemical Properties
    101 紫外可见吸收光谱 UV-VIS Absorption Spectra
    分光光度法 Spectrophotometric Spectra
    102 熔点/熔点范围 Melting Point/Melting Range
    103 沸点 Boiling Point
    104 蒸汽压 Vapour Pressure
    105 水溶解度 Water Solubility
    106 吸附/解吸 Adsorption/Desorption
    107 分配系数(正辛醇/水)-摇瓶法                                                                   Partition Coefficient (n-octanol/water)-Shake Flask Method
    108 在水中形成配位化合物的能力-极谱法 Complex Formation Ability in Water-Polarographic Method
    109 液体和固体的密度 Density of Liquids and Solids
    110 颗粒物粒度分布/纤维长度和直径分布 Particle Size Distribution/Fibre Length and Diameter Distributions
    111 与pH有关的水解作用 Hydrolysis as a Function of pH
    112 在水中的离解常数 Dissociation Constants in Water
    113 热稳定性和空气中稳定性的筛选试验 Screening Test for Thermal Stability and Stability in Air
    114 液体的粘度 Viscosity of Liquids
    115 水溶液的表面张力 Surface Tension of Aqueous Solution
    116 固态和液态物质的脂溶性-烧瓶法 Fat Solubility of Solid and Liquid Substances-Flask Method
    117 分配系数(正辛醇/水)-高效液相色谱法 Partition(n-octanol/water),High Performance Liquid Chromatography(HPLC)Method
    118 凝胶渗透色谱法(GPC)测定聚合物的数均分子量及分子量分布 Determination of the Number Average Molecular Weight and the Molecular Weight Distribution of Polymers Using Gel Permeation Chromatography
    119 凝胶渗透色谱法(GPC)测定聚合物低分子量部分的含量 Determination of the Low Molecular Weight Content of a Polymer Using Gel Permeation Chromatography
    120 聚合物在水中的溶解/萃取行为 Solution/Extraction Behaviour of Polymers in Water

    Section 2 Effects on Biotic Systems
    201 藻类生长抑制试验 Alga Growth Inhibition Test
    202 溞类24h EC50急性活动抑制试验 Daphnia sp.24h EC50 Acute Immobilization Test
    203 鱼类急性毒性试验 Fish Acute toxicity Test
    204 鱼类14天延长毒性试验 Fish, Prolonged Toxicity Test:14-day Study
    205 鸟类日粮毒性试验 Avian Dietary Toxicity Test
    206 鸟类繁殖试验 Avian Reproduction Test
    207 蚯蚓急性毒性试验 Earthworm, Acute Toxicity Test
    208 陆生植物生长试验 Terrestrial Plants, Growth Test
    209 活性污泥呼吸抑制试验 Activated Sludge, Respiration Inhibition Test
    210 鱼类早期生活阶段毒性试验 Fish, Early-life Stage Toxicity Test
    211 大型溞繁殖试验 Daphnia magna Reproduction Test
    212 鱼类胚胎-卵黄囊吸收阶段的短期毒性试验 Fish, Short-term Toxicity Test on Embryo and sac-fry Stages
    213 蜜蜂急性经口毒性试验 Honeybees, Acute Oral Toxicity Test
    214 蜜蜂急性接触毒性试验 Honeybees, Acute Contact Toxicity Test
    215 鱼类幼体生长试验 Fish, Juvenile Growth Test
    216 土壤微生物:氮转化测试 Soil Microorganisms: Nitrogen Transformation Test
    217 土壤微生物:碳转化测试 Soil Microorganisms: Carbon Transformation Test
    299 种子发芽和根伸长毒性试验 Seed Germination/Root Elongation Toxicity Test

    Section 3 Degradation and Accumulation
    301 快速生物降解性 Ready Biodegradability
    301 301A DOC消减试验 DOC Die-Away Test
    301B CO2产生试验 CO2 Evolution Test
    301C 改进的MITI试验(I) Modified MITI Test I
    301D 密闭瓶试验 Closed Bottle Test
    301E 改进的OECD筛选试验 Modified OECD Screening Test
    301F 呼吸计量法试验 Manomettric Respiremetry Test
    302 302A 改进的半连续活性污泥(SCAS)试验 Inherent Biodegradability: Modified SCAS Test
    302B 赞恩-惠伦斯试验 Zahn-Wellens Test
    302C 改进的MITI试验(II) Inherent Biodegradability: Modified MITI Test II
    303A 模拟试验—好氧污水处理:偶联单元试验 Simulation Test-Aerobic Sewage Treatment: Coupled Units Tests
    304A 土壤固有生物降解能力 Inherent Biodegradability in Soil
    305 流水式鱼类试验 Bioconcentration: Flow-Through Fish Test
    305 305A 连续静态鱼类试验 Bioconcentration: Sequential Static Fish Test
    305B 半静态鱼类试验 Bioconcentration: Semi-Static Fish Test
    305C 鱼类生物富集试验 Bioconcentration: Test for the Degree of Bioconcentration in Fish
    305D 静态鱼类试验 Bioconcentration: Static Fish Test
    399 吸收和蓄积试验 Update and Accumulation Test

    Section 4 Health Effects
    401 急性经口毒性试验 Acute Oral Toxicity Test
    402 急性经皮毒性试验 Acute Dermal Toxicity Test
    403 急性吸入毒性试验 Acute Inhalation Toxicity Test
    404 急性皮肤刺激性/腐蚀性试验 Acute Dermal Irritation/Corrosion Test
    405 急性眼刺激性/腐蚀性试验 Acute Eye Irritation/Corrosion Test
    406 皮肤致敏试验 Skin Sensitization Test
    407 啮齿类动物28天反复经口毒性试验 Repeated Dose 28-day Oral Toxicity Study in Rodents
    408 啮齿类动物亚慢性(90天)经口毒性试验 Repeated Dose 90-day Oral Toxicity Study in Rodents
    409 非啮齿类动物亚慢性(90天)经口毒性试验 Repeated Dose 90-day Oral Toxicity Study in Nonrodents
    410 反复经皮毒性:21/28天试验 Repeated Dose Dermal Toxicity:21/28-day Study
    411 亚慢性经皮毒性:90天试验 Subchronic Dermal Toxicity:90-day Study
    412 反复吸入毒性:28天或14天试验 Repeated Dose Inhalation Toxicity:28/14-day Study
    413 亚慢性吸入毒性:90天试验 Subchronic Inhalation Toxicity:90-day Study
    414 致畸试验 Teratogenicity
    415 一代繁殖毒性试验 One-Generation Reproduction Toxicity Study
    416 两代繁殖毒性试验 Two-Generation Reproduction Toxicity Study
    417 毒代动力学试验 Toxicokinetics Study
    418 有机磷化合物急性染毒的迟发性神经毒性试验 Delayed Neurotoxicity of Organophosphorus Substances Following Acute Exposure
    419 有机磷化合物亚慢性(28天)染毒的迟发性神经毒性试验 Delayed Neurotoxicity of Organophosphorus Substances:28-Day Repeated Dose Study
    420 急性经口毒性:固定剂量法 Acute Oral Toxicity-Fixed Dose Method
    421 生殖和发育毒性筛选试验 Reproduction/Developmental Toxicity Screening Test
    422 结合反复染毒毒性研究的生殖发育毒性筛选试验 Combined Repeated Dose Toxicity Study with the Reproduction/Developmental Toxicity Screening Test
    423 急性经口毒性:急性毒性的阶层法 Acute Oral Toxicity-Acute Toxic Class Method
    424 啮齿类动物的神经毒性试验 Neurotoxicity Study in Rodents
    425 急性经口毒性:上下增减剂量法 Acute Oral Toxicity-Up and Down Procedure
    451 致癌试验 Carcinogenicity Studies
    452 慢性毒性试验 Chronic Toxicity Studies
    453 慢性毒性与致癌性联合试验 Combined Chronic Toxicity/Carcinogenicity Studies
    471/472 细菌回复突变试验 Bacterial Reverse Mutation Test
    473 体外哺乳动物细胞染色体畸变试验 In vitro Mammalian Chromosome Aberration Test
    474 哺乳动物红细胞微核试验 Mammalian Erythocyte Micronucleus Test
    475 哺乳动物骨髓染色体畸变试验 Mammalian Bone Marrow Chromosome Aberration Test
    476 体外哺乳动物细胞基因突变试验 In vitro Mammalian Cell Gene Mutation Test
    477 黑腹果蝇伴性隐性致死试验 Sex-linked Recessive Lethal Test in Drosophila Melanogaster, SLRL
    478 啮齿类动物显性致死试验 Rodent Dominant Lethal Test
    479 哺乳类动物细胞姐妹染色单体互换体外试验 In vitro Sister Chromatid Exchange Assay in Mammalian 
    480 酿酒酵母基因突变试验 Saccharomyces cerevisiae, Gene Mutation Assay
    481 酿酒酵母有丝分裂重组试验 Saccharomyces cerevisiae Mitotic Recombination Assay
    482 哺乳类动物细胞DNA损害与修复/程序外DNA合成体外试验 DNA Damage and Repair/Unscheduled DNA Synthesis in Mammalian Cells in vitro
    483 哺乳动物精原细胞染色体畸变试验 Mammalian Spermatogonial Chromosome Aberration Test
    484 小鼠斑点试验 Mouse Spot Test
    485 小鼠可遗传易位试验 Mouse Heritable Translocation Assay
    486 体外哺乳动物肝细胞程序外DNA合成(UDS)试验 Unscheduled DNA Synthesis (UDS)Test with Mammalian Liver Cells in vitro
    490 空斑形成细胞试验 Plaque Forming Cell Assay
    491 迟发性超敏反应试验 Delayed Type Hypersensitivity Test
    492 自然杀伤细胞活性试验 Natural Killer Cell Activity Assay

    Flow Chart of NCSN

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